/*========================================================================= * * Copyright NumFOCUS * * Licensed under the Apache License, Version 2.0 (the "License"); * you may not use this file except in compliance with the License. * You may obtain a copy of the License at * * https://www.apache.org/licenses/LICENSE-2.0.txt * * Unless required by applicable law or agreed to in writing, software * distributed under the License is distributed on an "AS IS" BASIS, * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. * See the License for the specific language governing permissions and * limitations under the License. * *=========================================================================*/ #ifndef itkSymmetricForcesDemonsRegistrationFunction_hxx #define itkSymmetricForcesDemonsRegistrationFunction_hxx #include "itkMacro.h" #include "itkMath.h" namespace itk { template SymmetricForcesDemonsRegistrationFunction:: SymmetricForcesDemonsRegistrationFunction() { RadiusType r; r.Fill(0); this->SetRadius(r); m_TimeStep = 1.0; m_DenominatorThreshold = 1e-9; m_IntensityDifferenceThreshold = 0.001; this->SetMovingImage(nullptr); this->SetFixedImage(nullptr); m_FixedImageSpacing.Fill(1.0); m_Normalizer = 0.0; m_FixedImageGradientCalculator = GradientCalculatorType::New(); auto interp = DefaultInterpolatorType::New(); m_MovingImageInterpolator = static_cast(interp.GetPointer()); m_Metric = NumericTraits::max(); m_SumOfSquaredDifference = 0.0; m_NumberOfPixelsProcessed = 0L; m_RMSChange = NumericTraits::max(); m_SumOfSquaredChange = 0.0; } template void SymmetricForcesDemonsRegistrationFunction::PrintSelf(std::ostream & os, Indent indent) const { Superclass::PrintSelf(os, indent); os << indent << "FixedImageSpacing: " << static_cast::PrintType>(m_FixedImageSpacing) << std::endl; os << indent << "FixedImageOrigin: " << static_cast::PrintType>(m_FixedImageOrigin) << std::endl; os << indent << "Normalizer: " << m_Normalizer << std::endl; itkPrintSelfObjectMacro(FixedImageGradientCalculator); itkPrintSelfObjectMacro(MovingImageInterpolator); os << indent << "TimeStep: " << static_cast::PrintType>(m_TimeStep) << std::endl; os << indent << "DenominatorThreshold: " << m_DenominatorThreshold << std::endl; os << indent << "IntensityDifferenceThreshold: " << m_IntensityDifferenceThreshold << std::endl; os << indent << "Metric: " << m_Metric << std::endl; os << indent << "SumOfSquaredDifference: " << m_SumOfSquaredDifference << std::endl; os << indent << "NumberOfPixelsProcessed: " << static_cast::PrintType>(m_NumberOfPixelsProcessed) << std::endl; os << indent << "RMSChange: " << m_RMSChange << std::endl; os << indent << "SumOfSquaredChange: " << m_SumOfSquaredChange << std::endl; } template void SymmetricForcesDemonsRegistrationFunction:: SetIntensityDifferenceThreshold(double threshold) { m_IntensityDifferenceThreshold = threshold; } template double SymmetricForcesDemonsRegistrationFunction:: GetIntensityDifferenceThreshold() const { return m_IntensityDifferenceThreshold; } template void SymmetricForcesDemonsRegistrationFunction::InitializeIteration() { if (!this->GetMovingImage() || !this->GetFixedImage() || !m_MovingImageInterpolator) { itkExceptionMacro("MovingImage, FixedImage and/or Interpolator not set"); } // cache fixed image information m_FixedImageSpacing = this->GetFixedImage()->GetSpacing(); // compute the normalizer m_Normalizer = 0.0; for (unsigned int k = 0; k < ImageDimension; ++k) { m_Normalizer += m_FixedImageSpacing[k] * m_FixedImageSpacing[k]; } m_Normalizer /= static_cast(ImageDimension); // setup gradient calculator m_FixedImageGradientCalculator->SetInputImage(this->GetFixedImage()); // setup moving image interpolator m_MovingImageInterpolator->SetInputImage(this->GetMovingImage()); // initialize metric computation variables m_SumOfSquaredDifference = 0.0; m_NumberOfPixelsProcessed = 0L; m_SumOfSquaredChange = 0.0; } template auto SymmetricForcesDemonsRegistrationFunction::ComputeUpdate( const NeighborhoodType & it, void * gd, const FloatOffsetType & itkNotUsed(offset)) -> PixelType { auto * globalData = (GlobalDataStruct *)gd; const IndexType FirstIndex = this->GetFixedImage()->GetLargestPossibleRegion().GetIndex(); const IndexType LastIndex = this->GetFixedImage()->GetLargestPossibleRegion().GetIndex() + this->GetFixedImage()->GetLargestPossibleRegion().GetSize(); const IndexType index = it.GetIndex(); // Get fixed image related information // Note: no need to check the index is within // fixed image buffer. This is done by the external filter. const auto fixedValue = static_cast(this->GetFixedImage()->GetPixel(index)); const CovariantVectorType fixedGradient = m_FixedImageGradientCalculator->EvaluateAtIndex(index); // Get moving image related information IndexType tmpIndex = index; PointType mappedNeighPoint; CovariantVectorType movingGradient; const DisplacementFieldType * const field = this->GetDisplacementField(); using DisplacementPixelType = typename DisplacementFieldType::PixelType; PointType mappedCenterPoint; this->GetFixedImage()->TransformIndexToPhysicalPoint(index, mappedCenterPoint); for (unsigned int dim = 0; dim < ImageDimension; ++dim) { mappedCenterPoint[dim] += it.GetCenterPixel()[dim]; // bounds checking if (index[dim] < (FirstIndex[dim] + 1) || index[dim] > (LastIndex[dim] - 2)) { movingGradient[dim] = 0.0; } else { tmpIndex[dim] += 1; DisplacementPixelType displacement = field->GetPixel(tmpIndex); this->GetFixedImage()->TransformIndexToPhysicalPoint(tmpIndex, mappedNeighPoint); for (unsigned int j = 0; j < ImageDimension; ++j) { mappedNeighPoint[j] += displacement[j]; } if (m_MovingImageInterpolator->IsInsideBuffer(mappedNeighPoint)) { movingGradient[dim] = m_MovingImageInterpolator->Evaluate(mappedNeighPoint); } else { movingGradient[dim] = 0.0; } tmpIndex[dim] -= 2; displacement = field->GetPixel(tmpIndex); this->GetFixedImage()->TransformIndexToPhysicalPoint(tmpIndex, mappedNeighPoint); for (unsigned int j = 0; j < ImageDimension; ++j) { mappedNeighPoint[j] += displacement[j]; } if (m_MovingImageInterpolator->IsInsideBuffer(mappedNeighPoint)) { movingGradient[dim] -= m_MovingImageInterpolator->Evaluate(mappedNeighPoint); } movingGradient[dim] *= 0.5 / m_FixedImageSpacing[dim]; tmpIndex[dim] += 1; } } double movingValue = 0.0; if (m_MovingImageInterpolator->IsInsideBuffer(mappedCenterPoint)) { movingValue = m_MovingImageInterpolator->Evaluate(mappedCenterPoint); } /** * Compute Update. * In the original equation the denominator is defined as * * (g-f)^2 + (moving_grad+fixed_grad)_mag^2 * * However there is a mismatch in units between the two terms. * The units for the second term is intensity^2/mm^2 while the * units for the first term is intensity^2. This mismatch is particularly * problematic when the fixed image does not have unit spacing. * In this implementation, we normalize the first term by a factor K, * such that denominator = (g-f)^2/K + grad_mag^2 * where K = mean square spacing to compensate for the mismatch in units. */ double fixedPlusMovingGradientSquaredMagnitude = 0; for (unsigned int dim = 0; dim < ImageDimension; ++dim) { fixedPlusMovingGradientSquaredMagnitude += itk::Math::sqr(fixedGradient[dim] + movingGradient[dim]); } const double speedValue = fixedValue - movingValue; const double denominator = itk::Math::sqr(speedValue) / m_Normalizer + fixedPlusMovingGradientSquaredMagnitude; PixelType update; if (itk::Math::abs(speedValue) < m_IntensityDifferenceThreshold || denominator < m_DenominatorThreshold) { update.Fill(0.0); } else { for (unsigned int j = 0; j < ImageDimension; ++j) { update[j] = 2 * speedValue * (fixedGradient[j] + movingGradient[j]) / denominator; } } // update the squared change value PointType newMappedCenterPoint; bool IsOutsideRegion = false; for (unsigned int j = 0; j < ImageDimension; ++j) { if (globalData) { globalData->m_SumOfSquaredChange += itk::Math::sqr(update[j]); newMappedCenterPoint[j] = mappedCenterPoint[j] + update[j]; if (index[j] < (FirstIndex[j] + 2) || index[j] > (LastIndex[j] - 3)) { IsOutsideRegion = true; } } } // update the metric with the latest deformable field if (globalData) { // do not consider voxel on the border (2 voxels) as there are often // artifacts // which falsify the metric if (!IsOutsideRegion) { double newMovingValue = 0.0; if (m_MovingImageInterpolator->IsInsideBuffer(newMappedCenterPoint)) { newMovingValue = m_MovingImageInterpolator->Evaluate(newMappedCenterPoint); } globalData->m_SumOfSquaredDifference += itk::Math::sqr(fixedValue - newMovingValue); globalData->m_NumberOfPixelsProcessed += 1; } } return update; } template void SymmetricForcesDemonsRegistrationFunction::ReleaseGlobalDataPointer( void * gd) const { const std::unique_ptr globalData(static_cast(gd)); const std::lock_guard lockGuard(m_MetricCalculationMutex); m_SumOfSquaredDifference += globalData->m_SumOfSquaredDifference; m_NumberOfPixelsProcessed += globalData->m_NumberOfPixelsProcessed; m_SumOfSquaredChange += globalData->m_SumOfSquaredChange; if (m_NumberOfPixelsProcessed) { m_Metric = m_SumOfSquaredDifference / static_cast(m_NumberOfPixelsProcessed); m_RMSChange = std::sqrt(m_SumOfSquaredChange / static_cast(m_NumberOfPixelsProcessed)); } } } // end namespace itk #endif